The Sosnick Group at The University of Chicago

The Sosnick Group strives to characterize the general principles that guide protein folding and dynamics. We combine multiple experimental and computational approaches to characterize the behavior of proteins in diverse contexts

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Protein Folding - the 70% Rule

We have found that for many small 2-state proteins, the rate-limiting step of folding - the transition state - has ~70% of the native topology, according to the relative contact order.

Molecular Dynamics on your laptop!

Wouldn't it be nice to have physically realistic MD trajectories of protein dynamics without needing cpu-weeks/months of simulations? We have developed an MD engine that can reversibly fold some proteins up to 97 amino acids in cpu-days without requiring the use of fragments, homology or evolution.

Paper Published 07/28/2017

John Jumper

Congratulations to John Jumper on publishing his paper "Trajectory-Based Parameterization of a Coarse-Grained Forcefield for High-Throughput Protein Simulation", which is now available on bioRxiv.

Welcome 06/13/2017

Kayvon Tabrizi

Welcome to Kayvon Tabrizi, who is joining our group as a Summer Undergraduate Researcher

Congratulations 06/01/2017

Darren Kahan

Congratulations to Darren Kahan for being named an IBD scholar to support his research during the Summer

F1000Prime Recommendation 05/18/2017

Joshua Riback

Congratulations to Joshua Riback and our collaborators in the Drummond lab on having their Cell paper, entitled "Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response", recommended in F1000prime

Protein Folding

Protein Folding

Predicting Folding Dynamics

Predicting Folding Dynamics

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Membrane Proteins

Membrane Proteins

Psi analysis

Psi analysis

Conformational Entropy

Conformational Entropy

J.A. Riback*, C.D. Katanski*, J.L. Kear-Scott, E.V. Pilipenko, A.E. Rojek, T.R. Sosnick, D.A. Drummond, "Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response" Cell 168 (2017) 1028-40.

***Recommended in F1000prime***

A.R. French, T.R. Sosnick, R.S. Rock, "Investigations of human myosin VI targeting using optogenetically controlled cargo loading" Proc Natl Acad Sci U S A 114 (2017) E1607-16.

***Recommended in "F1000prime".***

Z.P. Gates*, M.C. Baxa*, W. Yu, J.A. Riback, H. Li, B. Roux, S.B.H. Kent, T.R. Sosnick, "Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core" Proc Natl Acad Sci U S A 114 (2017) 2241-6.

***Recommended in F1000Prime***

B. Basanta, K.K. Chan, P. Barth, T. King, T.R. Sosnick, J.R. Hinshaw, G. Liu, J.K. Everett, R. Xiao, G.T. Montelione, D. Baker, "Introduction of a polar core into the de novo designed protein Top7" Protein Sci 25 (2016) 1299-307.

University of Chicago
Biochemistry & Molecular Biophsyics
Biophysical Sciences
Institute for Molecular Engineering
Institute for Biophysical Dynamics
NSF Graduate Research Fellowship