The Sosnick Group at The University of Chicago


The Sosnick Group strives to characterize the general principles that guide protein folding and dynamics. We combine multiple experimental and computational approaches to characterize the behavior of proteins in diverse contexts


 

Protein Folding - the 70% Rule

We have found that for many small 2-state proteins, the rate-limiting step of folding - the transition state - has ~70% of the native topology, according to the relative contact order.

Molecular Dynamics on your laptop!

Wouldnt it be nice to have physically realistic MD trajectories of protein dynamics without needing cpu-weeks/months of simulations? We have developed an MD engine that can reversibly fold some proteins up to 97 amino acids in cpu-days without requiring the use of fragments, homology or evolution.

Paper Published 03/09/2017

Joshua Riback

Congratulations to Josh Riback and our collaborators in the Drummond lab on having their paper, entitled "Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response", published in Cell.

F1000Prime Recommendation 02/28/2017

Alexander French

Congratulations to Alex French in collaboration with the Rock group on having their PNAS paper, entitled "An Optogenetic Method for Controlling Full-Length Myosin VI through its Cargo Binding Domain", recommended in F1000Prime.

F1000Prime Recommendation 02/27/2017

Michael BaxaWookyung YuJoshua Riback

Congratulations to Michael Baxa, Wookyung Yu, Joshua Riback, and our collaborators in the Roux and Kent groups on having their PNAS paper, entitled "Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core", recommended in F1000Prime.

Paper Published 02/13/2017

Alexander French

Congratulations to Alex French in collaboration with the Rock group on having his paper, entitled "An Optogenetic Method for Controlling Full-Length Myosin VI through its Cargo Binding Domain", published in PNAS.

Protein Folding

Protein Folding

Predicting Folding Dynamics

Predicting Folding Dynamics

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Membrane Proteins

Membrane Proteins

Psi analysis

Psi analysis

J.A. Riback*, C.D. Katanski*, J.L. Kear-Scott, E.V. Pilipenko, A.E. Rojek, T.R. Sosnick, D.A. Drummond, "Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response" Cell 168 (2017) 1028-40.

A.R. French, T.R. Sosnick, R.S. Rock, "Investigations of human myosin VI targeting using optogenetically controlled cargo loading" Proc Natl Acad Sci U S A 114 (2017) E1607-16.

Z.P. Gates*, M.C. Baxa*, W. Yu, J.A. Riback, H. Li, B. Roux, S.B.H. Kent, T.R. Sosnick, "Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core" Proc Natl Acad Sci U S A 114 (2017) 2241-6.

B. Basanta, K.K. Chan, P. Barth, T. King, T.R. Sosnick, J.R. Hinshaw, G. Liu, J.K. Everett, R. Xiao, G.T. Montelione, D. Baker, "Introduction of a polar core into the de novo designed protein Top7" Protein Sci 25 (2016) 1299-307.

M.J. Poellmann, T.R. Sosnick, S.C. Meredith, R.C. Lee, "The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme" Macromol Biosci (2016).

J.R. Sachleben, A.N. Adhikari, G. Gawlak, R.J. Hoey, G. Liu, A. Joachimiak, G.T. Montelione, T.R. Sosnick, S. Koide, "Aromatic claw: A new fold with high aromatic content that evades structural prediction" Protein Sci (2016).

University of Chicago
Biochemistry & Molecular Biophsyics
Biophysical Sciences
Institute for Molecular Engineering
Institute for Biophysical Dynamics
UChicago
NSF Graduate Research Fellowship
NIH