Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

We have actively studied the biophysical dynamics in a photoswitchable protein (LOV2 domain) and used it's photocycle to engineer light-controlled protein machines

Approach

    J.P. Zayner, T.R. Sosnick, "Factors that control the chemistry of the LOV domain photocycle" PLoS One 9 (2014) e87074.

    J.P. Zayner, C. Antoniou, A.R. French, R.J. Hause, Jr., T.R. Sosnick, "Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated protein" Biophys J 105 (2013) 1027-36.

    D. Strickland, Y. Lin, E. Wagner, C.M. Hope, J. Zayner, C. Antoniou, T.R. Sosnick, E.L. Weiss, M. Glotzer, "TULIPs: tunable, light-controlled interacting protein tags for cell biology" Nat Methods 9 (2012) 379-84.