Research Areas

Who are we?

Protein Folding

Protein Folding

Predicting Folding Dynamics

Predicting Folding Dynamics

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Membrane Proteins

Membrane Proteins

Psi analysis

Psi analysis

Conformational Entropy

Conformational Entropy

J.A. Riback, M.A. Bowman, A.M. Zmyslowski, K.W. Plaxco, P.L. Clark, T.R. Sosnick, "Commonly used FRET fluorophores promote collapse of an otherwise disordered protein" Proc Natl Acad Sci U S A 116 (2019) 8889-94

J.P. Zayner, T. Mathes, T.R. Sosnick, J.T.M. Kennis, "Helical Contributions Mediate Light-Activated Conformational Change in the LOV2 Domain of Avena sativa Phototropin 1" ACS Omega 2019, 4(1) 1238-43.

J.M. Jumper, N.F. Faruk, K.F. Freed, T.R. Sosnick, "Accurate calculation of side chain packing and free energy with applications to protein molecular dynamics" PLoS Comput Biol 14(12): e1006342

J.M. Jumper, N.F. Faruk, K.F. Freed, T.R. Sosnick, "Trajectory-based training enables protein simulations with accurate folding and Boltzmann ensembles in cpu-hours" PLoS Comput Biol. 14(12): e1006578

Z. Wang, J.M. Jumper, S. Wang, K.F. Freed, T.R. Sosnick, "A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations." Biophysical Journal, 115 (2018) 1872-84.

University of Chicago
Biochemistry & Molecular Biophsyics
Biophysical Sciences
Institute for Molecular Engineering
Institute for Biophysical Dynamics
UChicago
NSF Graduate Research Fellowship
NIH