Research Areas

Who are we?

Protein Folding

Protein Folding

Predicting Folding Dynamics

Predicting Folding Dynamics

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Membrane Proteins

Membrane Proteins

Psi analysis

Psi analysis

Conformational Entropy

Conformational Entropy

A.M. Zmyslowski, M.C. Baxa, I.A. Gagnon, T.R. Sosnick, "HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain’s allostery and unfolding upon B12 and TonB binding" Proc Natl Acad Sci U S A 119 (2022).

K.A. Gaffney, R. Guo, M.D. Bridges, S. Muhammednazaar, D. Chen, M. Kim, Z. Yang, A.L. Schilmiller, N.F. Faruk, X. Peng, A.D. Jones, K.H. Kim, L. Sun, W.L. Hubbell, T.R. Sosnick, H. Hong, "Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein" Proc Natl Acad Sci U S A 119 (2022).

X. Peng, M.C. Baxa, N.F. Faruk, J.R. Sachleben, S. Pintscher, I.A. Gagnon, S. Houliston, C.H. Arrowsmith, K.F. Freed, G.J. Rocklin, T.R. Sosnick, "Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence." J Chem Theory Comput, 18 (2022) 550-61.

M.C. Baxa, T.R. Sosnick, "Engineered Metal-Binding Sites to Probe Protein Folding Transition States: Psi Analysis." Muñoz V. (eds) Protein Folding. Methods in Molecular Biology, vol 2376. (2021) 31-63.

K.C. Song, A.V. Molina, R. Chen, I.A. Gagnon, Y.H. Koh, B. Roux, T.R. Sosnick, "Folding and misfolding of potassium channel monomers during assembly and tetramerization" Proc Natl Acad Sci U S A 118 (2021).

University of Chicago
Biochemistry & Molecular Biophsyics
Biophysical Sciences
Institute for Molecular Engineering
Institute for Biophysical Dynamics
UChicago
NSF Graduate Research Fellowship
NIH