Research Areas

Who are we?

Protein Folding

Protein Folding

Predicting Folding Dynamics

Predicting Folding Dynamics

Photoswitchable allosteric proteins

Photoswitchable allosteric proteins

Membrane Proteins

Membrane Proteins

Psi analysis

Psi analysis

Conformational Entropy

Conformational Entropy

M.A. Bowman, J.A. Riback, A. Rodriguez, H. Guo, J. Li, T.R. Sosnick, P.L. Clark, T.R. Sosnick, "Properties of protein unfolded states suggest broad selection for expanded conformational ensembles" Proc Natl Acad Sci U S A 117 (2020) 23356-64.

P.L. Clark, K.W. Plaxco, T.R. Sosnick, "Water as a Good Solvent for Unfolded Proteins: Folding and Collapse are Fundamentally Different" J Mol Biol 432 (2020) 2882-89.

K. Leon, R.L. Cunningham, J.A. Riback, E. Feldman, J. Li, T.R. Sosnick, M. Zhao, K.R. Monk, D. AraƧ, "Structural basis for adhesion G protein-coupled receptor Gpr126 function" Nat Comm 11:194 (2020).

Z. Wang, J.M. Jumper, K.F. Freed, T.R. Sosnick, "On the Interpretation of Force-Induced Unfolding Studies of Membrane Proteins Using Fast Simulations" Biophysical Journal, 117 (2019) 1429-41.

J.A. Riback, M.A. Bowman, A.M. Zmyslowski, K.W. Plaxco, P.L. Clark, T.R. Sosnick, "Commonly used FRET fluorophores promote collapse of an otherwise disordered protein" Proc Natl Acad Sci U S A 116 (2019) 8889-94

University of Chicago
Biochemistry & Molecular Biophsyics
Biophysical Sciences
Institute for Molecular Engineering
Institute for Biophysical Dynamics
UChicago
NSF Graduate Research Fellowship
NIH