Tobin Sosnick Professor

Tobin Sosnick

Tobin Sosnick
Professor at The University of Chicago

Ph.D. Applied Physics, Harvard University, 1989
M.S. Applied Physics, Harvard University, 1986
B.A. Physics, UC San Diego

GCIS W101C
929 East 57th Street
Chicago, IL 60637 USA

Biochemistry & Molecular Department Page
Biophysical Sciences Page
Molecular Engineering Page
Computation Institute

trsosnic@uchicago.edu
(773) 218-5950

My research program involves synergistic studies of proteinfolding, function and design, with both experimental and computational components. The research is based on the premise that rigorous and innovative studies of basic processes have broad implications in many areas of biological research. My experimental experience in protein folding, design, modeling, and biophysical methods provides an enormous benefit to our computational studies which heavily rely on the use of fundamental principles of protein folding.

My group is involved in many areas include delineating protein folding pathways, de novo structure prediction, design of light-triggered allosteric proteins, and membrane protein folding. My lab employs a range of experimental and computational methods including NMR, small-angle X-ray scattering, rapid mixing methods, hydrogen exchange, molecular dynamics and coarse-grain folding simulations. I am a very a strong believer in collaboration, having co-mentored 15+ students and post-doctoral fellows who produced 30+ papers in the last 10 years

University of Chicago, Department Chair 2011-
University of Chicago, Professor, 1996-

M.C. Baxa, X. Lin, C.D. Mukinay, S. Chakravarthy, J.R. Sacheleben, S. Antilla, N. Hartrampf, J.A. Riback, I.A. Gagnon, B.L. Pentelute, P.L. Clark, T.R. Sosnick, "How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins" Prot Sci 33(5):e4986 (2024).

H. Glauninger, J.A.M. Bard, C.W. Hickernell, E.M. Airoldi, W. Li, R.H. Singer, S. Paul, J. Fei, T.R. Sosnick, E.W.J. Wallace, D.A. Drummond, "Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts" bioRxiv 2024.04.15.589678

S.K. Kik, D. Christopher, H. Glauninger, C.W. Hickernell, J.A.M. Bard, M. Ford, T.R. Sosnick, D.A. Drummond, "An adaptive biomolecular condensation response is conserved across environmentally divergent species" Nat Comm 15, 3127 (2024).

X. Lin, P. Haller, N. Bavi, N. Faruk, E. Perozo, T.R. Sosnick, "Folding of Prestin’s Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility" eLife 12:RP89635

K.L. Kroll, A.R. French, T.R. Sosnick, R.S. Rock, "LILAC: enhanced actin imaging with an optogenetic Lifeact" Nature Methods 20 (2023).

S. Chen, M. Hassan, R.L. Jernigan, K. Jia, D. Kihara, A. Kloczkowski, S. Kotelnikov, D. Kozakov, J. Liang, A. Liwo, S. Matysiak, J. Meller, C. Micheletti, J.C. Mitchell, S. Mondal, R. Nussinov, K. Okazaki, D. Padhorny, J. Skolnick, T.R. Sosnick, G. Stan, I. Vakser, X. Zou, G.D. Rose, "Protein folds vs. protein folding: Differing questions, different challenges" Proc Natl Acad Sci U S A 120 (1) (2023).

X. Lin, A.M. Zmyslowski, I.A. Gagnon, R.K. Nakamoto, T.R. Sosnick, "Development of in vivo HDX-MS with applications to a TonB-dependent transporter and other proteins" Protein Science 31 (9) (2022).

K.A. Gaffney, R. Guo, M.D. Bridges, S. Muhammednazaar, D. Chen, M. Kim, Z. Yang, A.L. Schilmiller, N.F. Faruk, X. Peng, A.D. Jones, K.H. Kim, L. Sun, W.L. Hubbell, T.R. Sosnick, H. Hong, "Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein" Proc Natl Acad Sci U S A 119 (2022).