Ph.D. Applied Physics, Harvard University, 1989
M.S. Applied Physics, Harvard University, 1986
B.A. Physics, UC San Diego
929 East 57th Street
Chicago, IL 60637 USA
My research program involves synergistic studies of proteinfolding, function and design, with both experimental and computational components. The research is based on the premise that rigorous and innovative studies of basic processes have broad implications in many areas of biological research. My experimental experience in protein folding, design, modeling, and biophysical methods provides an enormous benefit to our computational studies which heavily rely on the use of fundamental principles of protein folding.
My group is involved in many areas include delineating protein folding pathways, de novo structure prediction, design of light-triggered allosteric proteins, and membrane protein folding. My lab employs a range of experimental and computational methods including NMR, small-angle X-ray scattering, rapid mixing methods, hydrogen exchange, molecular dynamics and coarse-grain folding simulations. I am a very a strong believer in collaboration, having co-mentored 15+ students and post-doctoral fellows who produced 30+ papers in the last 10 years
University of Chicago, Department Chair 2011-
University of Chicago, Professor, 1996-
J.J. Skinner, S. Wang, J. Lee, C. Ong, R. Sommese, S. Sivaramakrishnan, W. Koelmel, M. Hirschbeck, H. Schindelin, C. Kisker, K. Lorenz, T.R. Sosnick, M.R. Rosner, "Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome." Proc Natl Acad Sci U S A 114 (2017) 13453-8.
J.R. Riback, M.A. Bowman, A.M. Zmyslowski, C.R. Knoverek, J.M. Jumper, J.R. Hinshaw, E.B. Haye, K.F. Freed, P.L. Clark, T.R. Sosnick, "Innovative scattering analysis shows hydrophobic disordered proteins are expanded in water" Science 358 (2017) 238-41.
J.M. Jumper, K.F. Freed, T.R. Sosnick, "Trajectory-Based Parameterization of a Coarse-Grained Forcefield for High-Throughput Protein Simulation" bioRxiv:169326.
J.A. Riback*, C.D. Katanski*, J.L. Kear-Scott, E.V. Pilipenko, A.E. Rojek, T.R. Sosnick, D.A. Drummond, "Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response" Cell 168 (2017) 1028-40.
***Recommended in F1000prime***
A.R. French, T.R. Sosnick, R.S. Rock, "Investigations of human myosin VI targeting using optogenetically controlled cargo loading" Proc Natl Acad Sci U S A 114 (2017) E1607-16.
***Recommended in "F1000prime".***
Z.P. Gates*, M.C. Baxa*, W. Yu, J.A. Riback, H. Li, B. Roux, S.B.H. Kent, T.R. Sosnick, "Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core" Proc Natl Acad Sci U S A 114 (2017) 2241-6.
***Recommended in F1000Prime***
J.M. Jumper, K.F. Freed, T.R. Sosnick, "Maximum-likelihood, self-consistent side chain free energies with applications to protein molecular dynamics" arXiv:1610.07277 [q-bio.BM].
B. Basanta, K.K. Chan, P. Barth, T. King, T.R. Sosnick, J.R. Hinshaw, G. Liu, J.K. Everett, R. Xiao, G.T. Montelione, D. Baker, "Introduction of a polar core into the de novo designed protein Top7" Protein Sci 25 (2016) 1299-307.
M.J. Poellmann, T.R. Sosnick, S.C. Meredith, R.C. Lee, "The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme" Macromol Biosci (2016).
J.R. Sachleben, A.N. Adhikari, G. Gawlak, R.J. Hoey, G. Liu, A. Joachimiak, G.T. Montelione, T.R. Sosnick, S. Koide, "Aromatic claw: A new fold with high aromatic content that evades structural prediction" Protein Sci (2016).