Tobin Sosnick Professor

Tobin Sosnick

Tobin Sosnick
Professor at The University of Chicago

Ph.D. Applied Physics, Harvard University, 1989
M.S. Applied Physics, Harvard University, 1986
B.A. Physics, UC San Diego

929 East 57th Street
Chicago, IL 60637 USA

Biochemistry & Molecular Department Page
Biophysical Sciences Page
Molecular Engineering Page
Computation Institute
(773) 218-5950

My research program involves synergistic studies of proteinfolding, function and design, with both experimental and computational components. The research is based on the premise that rigorous and innovative studies of basic processes have broad implications in many areas of biological research. My experimental experience in protein folding, design, modeling, and biophysical methods provides an enormous benefit to our computational studies which heavily rely on the use of fundamental principles of protein folding.

My group is involved in many areas include delineating protein folding pathways, de novo structure prediction, design of light-triggered allosteric proteins, and membrane protein folding. My lab employs a range of experimental and computational methods including NMR, small-angle X-ray scattering, rapid mixing methods, hydrogen exchange, molecular dynamics and coarse-grain folding simulations. I am a very a strong believer in collaboration, having co-mentored 15+ students and post-doctoral fellows who produced 30+ papers in the last 10 years

University of Chicago, Department Chair 2011-
University of Chicago, Professor, 1996-

S.K. Kik, D. Christopher, H. Glauninger, C.W. Hickernell, J.A.M. Bard, M. Ford, T.R. Sosnick, D.A. Drummond, "An adaptive biomolecular condensation response is conserved across environmentally divergent species" bioRxiv 2023.07.28.551061.

X. Lin, P. Haller, N. Bavi, N. Faruk, E. Perozo, T.R. Sosnick, "Folding of Prestin’s Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility" bioRxiv 2023.02.27.530320.

K.L. Kroll, A.R. French, T.R. Sosnick, R.S. Rock, "LILAC: enhanced actin imaging with an optogenetic Lifeact" Nature Methods 20 (2023).

S. Chen, M. Hassan, R.L. Jernigan, K. Jia, D. Kihara, A. Kloczkowski, S. Kotelnikov, D. Kozakov, J. Liang, A. Liwo, S. Matysiak, J. Meller, C. Micheletti, J.C. Mitchell, S. Mondal, R. Nussinov, K. Okazaki, D. Padhorny, J. Skolnick, T.R. Sosnick, G. Stan, I. Vakser, X. Zou, G.D. Rose, "Protein folds vs. protein folding: Differing questions, different challenges" Proc Natl Acad Sci U S A 120 (1) (2023).

X. Lin, A.M. Zmyslowski, I.A. Gagnon, R.K. Nakamoto, T.R. Sosnick, "Development of in vivo HDX-MS with applications to a TonB-dependent transporter and other proteins" Protein Science 31 (9) (2022).

A.M. Zmyslowski, M.C. Baxa, I.A. Gagnon, T.R. Sosnick, "HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain’s allostery and unfolding upon B12 and TonB binding" Proc Natl Acad Sci U S A 119 (2022).

K.A. Gaffney, R. Guo, M.D. Bridges, S. Muhammednazaar, D. Chen, M. Kim, Z. Yang, A.L. Schilmiller, N.F. Faruk, X. Peng, A.D. Jones, K.H. Kim, L. Sun, W.L. Hubbell, T.R. Sosnick, H. Hong, "Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein" Proc Natl Acad Sci U S A 119 (2022).

X. Peng, M.C. Baxa, N.F. Faruk, J.R. Sachleben, S. Pintscher, I.A. Gagnon, S. Houliston, C.H. Arrowsmith, K.F. Freed, G.J. Rocklin, T.R. Sosnick, "Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence." J Chem Theory Comput, 18 (2022) 550-61.

M.C. Baxa, T.R. Sosnick, "Engineered Metal-Binding Sites to Probe Protein Folding Transition States: Psi Analysis." Muñoz V. (eds) Protein Folding. Methods in Molecular Biology, vol 2376. (2021) 31-63.