Tobin Lectures


  • An introduction to protein structure. [PPT] [PDF]
  • The Central Dogma
  • Protein Structure
  • Primary Structure
  • Secondary Structure
  • More on protein structure. [PPT] [PDF]
  • Higher Order Structure
  • Denatured States
  • Thermodynamics and Proteins [PPT] [PDF]
  • Thermodynamics according to proteins
  • Electrostatics
  • van der Waals
  • Hydrogen Exchange in Proteins and Nucleic Acids [PPT] [PDF]
  • "Thermodynamics, kinetics, and structure all from one little proton"
  • Protein Folding: It's a Problem [PPT] [PDF]
  • Kinetics/mechanism of folding
  • Predicting structure from sequence
  • Spectroscopy, Absorbance, and Fluorescence [PPT] [PDF]
  • Predicting Structure Using Folding (2007) [PPT] [PDF]
  • Sedimentation Analysis, Electrostatics, Binding [PPT] [PDF]
  • Principles of macromolecular sedimentation analysis
  • Molecular Diffusion
  • Association and chemical kinetics - Eyring and Kramer
  • Electrostatic guiding: Poisson-Boltzmann, Debye-Huckel Screening
  • Ligand Binding and Linked Equilibrium
  • Small Angle X-ray Scattering (SAXS) [PPT] [PDF]
  • An introduction to nucleic acids [PPT] [PDF]
  • Nucleic acid structure
  • Protein - DNA interactions
  • DNA replication and Polymerases [PPT] [PDF]
  • RNA Folding [PPT] [PDF]
  • Sequence to Structure
  • Tertiary Motifs
  • Thermodynamics of folding
  • Methods for studying folding intermediates
  • Folding Pathways of RNA and Reduced Contact Order
  • RNA-ion interactions: Surprisingly complicated [PPT] [PDF]
  • Metal requirements for folding
  • What about monovalents?
  • Counter-ion condensation effect
  • Poisson-Boltzmann and its limits
  • Thermodynamics, Hill coefficients, and folding
  • Single Molecule and RNA Folding (2007) [PPT] [PDF]
  • DNA: Bending and SuperCoiling [PPT] [PDF]

 

Posted on January 26, 2009 by baxa  |